Biostimulators

starting at €299

Biostimulators are modern active ingredients used in aesthetic medicine that regenerate the skin from the inside out and specifically stimulate the body’s own collagen production. These include, among others, polynucleotides and calcium hydroxylapatite (Radiesse), which act deep within the skin and provide long-lasting structural improvement.

Unlike traditional fillers, biostimulators are not primarily intended to add volume, but rather to strengthen and firm the skin over the long term. They promote elasticity, improve skin quality, and result in a firmer, more even appearance.

Biostimulators are particularly effective for fine lines, loss of elasticity, and dull skin, as well as for treating acne scars and other types of scars. Over time, the skin appears smoother, firmer, and visibly rejuvenated—with a natural, healthy glow.

For optimal results, several sessions spaced a few weeks apart are generally recommended. Afterward, the results can be individually maintained to stabilize and preserve the skin’s condition over the long term.

Das Ergebnis ist keine Veränderung, sondern eine sichtbare Verbesserung der Hautqualität – natürlich, nachhaltig und auf Zellebene wirksam. Vereinbaren Sie jetzt Ihren Termin für Polynukleotide oder Radiesse in Berlin bei Dr. Caliskan und lassen sich umfassend beraten. Jeder Patient ist bei uns einzigartig und erhält eine umfassende Beratung.

Overview
Recognition of Income

Initial effects, such as improved skin hydration and a fresh glow, are often visible shortly after use, depending on the product chosen. The full effect develops over several weeks as a result of stimulated collagen production.

Shelf Life

The results generally last for several months. Stimulated collagen production can improve the skin's structure over the long term.

Overview
Downtime

There is generally no downtime. Mild redness or swelling may occur, but these usually subside within a short time.

Price

starting at €299

Services are billed in accordance with the Schedule of Fees for Physicians (GOÄ).
Important to Know
Risks & Possible Side Effects
  • Mild swelling, redness, or tenderness at the injection sites
  • Small hematomas (bruises) may occur
  • Temporary formation of nodules or hardening in the tissue
  • Rare inflammatory reactions or intolerances
Behavior Before and After Treatment

Before treatment:

  • If possible, avoid blood-thinning medications (after consulting your doctor) and alcohol.

After treatment:

  • Avoid strenuous physical activity, intense heat/sun, and saunas for 24–48 hours.
  • 24 hours without makeup.
  • Avoid putting pressure on the treated areas for 48 hours, if possible.
  • No active ingredients (retinol, AHA/BHA) for 5 days.
  • Depending on the product you choose, do not use Gua Sha for 1–2 months.

Treatment options with

Biostimulators

FAQ
What are biostimulants, and how do they work?

Biostimulatoren sind injizierbare Wirkstoffe, die die körpereigene Kollagenproduktion anregen. Anstatt Volumen direkt aufzubauen, verbessern sie die Hautstruktur von innen heraus und sorgen für eine natürliche Straffung und Festigkeit. Dr. Caliskan bietet in seiner Praxis für ästhetische Medizin in Berlin Mitte die Radiesse Behandlung sowie Polynukleotide an.

Who are biostimulators suitable for?

Die Polynukleotide oder Radiesse Behandlung eignet sich besonders bei nachlassender Hautelastizität, feinen Linien und beginnendem Volumenverlust. Ideal für alle, die ein natürliches Ergebnis ohne „aufgespritzten“ Effekt wünschen.diesse

What results can I expect from treatment with biostimulators?

The skin appears tighter, firmer, and fresher overall. The improvement occurs gradually, as collagen regeneration takes time—which is why the result looks particularly natural.

How long do the results of biostimulants last?

The results typically last 6 to 24 months, depending on the product used, skin condition, and lifestyle following repeated sessions.

How many sessions are needed?

In most cases, 2–3 treatments spaced several weeks apart are recommended to achieve optimal and long-lasting results.

What is the difference between biostimulators and traditional fillers?

While fillers provide immediate volume, biostimulators encourage the skin to produce its own collagen. The results take longer to develop, but they are longer-lasting and more natural-looking.

Why are biostimulants worthwhile in the long run?

Because the skin is strengthened from the inside out, its quality improves over the long term. Biostimulators are an effective way to slow down skin aging in the long term and improve skin texture.

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